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Literature summary extracted from
- A ribonuclease zymogen activated by the NS3 protease of the hepatitis C virus (2006), FEBS J., 273, 5457-5465.
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 4.6.1.18 | expression in Escherichia coli | Homo sapiens |
| 4.6.1.18 | expression in Escherichia coli | Bos taurus |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 4.6.1.18 | H2O2 | - |
Bos taurus |  |
| 4.6.1.18 | H2O2 | - |
Homo sapiens | |
| 4.6.1.18 | ribonuclease inhibitor | extremely tight complex with bovine ribonuclease inhibitor, Kd value 0.69 fM. Kd value of complex with human ribonuclease inhibitor 0.34 fM | Bos taurus | |
| 4.6.1.18 | ribonuclease inhibitor | tight complex with human ribonuclease inhibitor, Kd value 0.34 fM. Kd value of complex with bovine ribonuclease inhibitor 35 fM | Homo sapiens | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 4.6.1.18 | Bos taurus | - |
- |
- |
| 4.6.1.18 | Homo sapiens | - |
- |
- |
Temperature Range [°C]
| EC Number | Temperature Minimum [°C] | Temperature Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 4.6.1.18 | 66.6 | - |
melting temperature of complex with human ribonuclease inhibitor | Homo sapiens |
| 4.6.1.18 | 68 | - |
melting temperature of complex with bovine ribonuclease inhibitor | Homo sapiens |
Temperature Stability [°C]
| EC Number | Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 4.6.1.18 | 64.2 | - |
melting temperature of complex with human ribonuclease inhibitor | Bos taurus |
| 4.6.1.18 | 68.6 | - |
melting temperature of complex with bovine ribonuclease inhibitor | Bos taurus |
IC50 Value
| EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|---|
| 4.6.1.18 | 0.028 | - |
oxidative stability of complex with human ribonuclease inhibitor | Homo sapiens | H2O2 | |
| 4.6.1.18 | 0.029 | - |
oxidative stability of complex with bovine ribonuclease inhibitor | Homo sapiens | H2O2 | |
| 4.6.1.18 | 0.042 | - |
oxidative stability of complex with human ribonuclease inhibitor | Bos taurus | H2O2 | |
| 4.6.1.18 | 0.3 | - |
oxidative stability of complex with bovine ribonuclease inhibitor | Bos taurus | H2O2 | |
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Release 2023.1 (January 2023)
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